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1994-08-09
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Document 0152
DOCN M9480152
TI Significance of interleukin 6 in patients with sarcoidosis.
DT 9410
AU Sahashi K; Ina Y; Takada K; Sato T; Yamamoto M; Morishita M; Second
Department of Internal Medicine, Nagoya City, University; Medical
School, Japan.
SO Chest. 1994 Jul;106(1):156-60. Unique Identifier : AIDSLINE MED/94291373
AB Interleukin 6 (IL-6) levels in various materials from patients with
sarcoidosis were determined. The subjects of the study were 38 patients
with sarcoidosis and 28 healthy controls. For detection of IL-6, an
enzyme-linked immunosorbent assay method was used. Interleukin 6
activity in serum was detected in 4 of 30 patients, but not in 19
controls. In bronchoalveolar lavage (BAL) fluid, following 20-fold
concentration, IL-6 activity was detected in four of ten patients
(nonsmokers) and three of seven controls (two of two smokers and one of
five nonsmokers). Interleukin 6 levels in the supernatants of cultured
monocytes and alveolar macrophages (AMs) were significantly higher (p <
0.01 and p < 0.01, respectively) in patients with sarcoidosis than in
controls. Interleukin 6 production from monocytes tended to correlate
with that from AMs. A significant correlation (r = 0.70, p < 0.05) was
found between IL-6 production from AMs and the ratio of CD4+/CD8+ in BAL
fluid, although no correlation was observed between that from monocytes
and CD4+/CD8+ ratio in BAL fluid. Taken together, IL-6 may be involved
in the initiation and maintenance of alveolitis by activating and
causing the proliferation of T cells.
DE Adult Bronchoalveolar Lavage Fluid/CHEMISTRY Cells, Cultured CD4-CD8
Ratio Female Human Interleukin-6/*ANALYSIS Macrophages,
Alveolar/METABOLISM Male Middle Age Monocytes/METABOLISM
Sarcoidosis/IMMUNOLOGY/*METABOLISM Support, Non-U.S. Gov't Tumor
Necrosis Factor/ANALYSIS JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).